A Hydrophobic Region Locating at the Center of Fibroblast Growth Factor-9 Is Crucial for Its Secretion

Fibroblast growth factor (FGF)-9 is a glycosylated neurotrophic polypeptide highly expressed in brain. The mechanism for its secretion from expressing cells is unclear, because its primary structure lacks a cleavable signal sequence. We, therefore, investigated the mechanism and structural requireme...

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Veröffentlicht in:	The Journal of biological chemistry 1999-10, Vol.274 (41), p.29352-29357
Hauptverfasser:	Miyakawa, Kazuko, Hatsuzawa, Kiyotaka, Kurokawa, Tsutomu, Asada, Masahiro, Kuroiwa, Tomoko, Imamura, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals COS Cells DNA Primers Fibroblast Growth Factor 9 Fibroblast Growth Factors Glycosylation Growth Substances - chemistry Growth Substances - genetics Growth Substances - metabolism Microsomes - metabolism Molecular Sequence Data Mutation Protein Biosynthesis Protein Sorting Signals Rabbits Rats Reticulocytes signal recognition particle Signal Recognition Particle - metabolism Transfection Triticum
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