A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions

The trifluoroacetyl group protects the nucleophilic HYNIC from unwanted side reactions yet allows radiolabelling with technetium-99m under mild conditions, due to efficient and specific promotion of deprotection by a technetium complex intermediate.

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Bibliographische Detailangaben
Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2008-06 (22), p.2920-2922
Hauptverfasser:	Surfraz, M Bashir-Uddin, Biagini, Stefano C G, Blower, Philip J
Format:	Artikel
Sprache:	eng
Schlagworte:	Hydrazines - chemistry Isotope Labeling - methods Molecular Structure Nicotinic Acids - chemistry Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Technetium - chemistry Time Factors
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The trifluoroacetyl group protects the nucleophilic HYNIC from unwanted side reactions yet allows radiolabelling with technetium-99m under mild conditions, due to efficient and specific promotion of deprotection by a technetium complex intermediate.
ISSN:	1477-9226 1477-9234
DOI:	10.1039/b805110k