A Concise Asymmetric Synthesis of Torcetrapib

A Concise Asymmetric Synthesis of Torcetrapib

Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.

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Veröffentlicht in:Journal of organic chemistry 2007-08, Vol.72 (16), p.6290-6293
Hauptverfasser: Guinó, Meritxell, Phua, Pim Huat, Caille, Jean-Claude, Hii, King Kuok (Mimi)
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemistry
Carbamates - chemistry
Catalysis
Chemistry
Chemistry, Organic - methods
Exact sciences and technology
Models, Chemical
Molecular Conformation
Molecular Structure
Organic chemistry
Quinolines - chemical synthesis
Quinolines - chemistry
Stereoisomerism
Time Factors
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Beschreibung
Zusammenfassung:Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo071031g