Comparison of single vs. multiple administrations of the AMPA receptors modulator S 18986 in the object recognition task in rats

The present study aimed at defining the best scheme of administration of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor‐positive modulator (S)‐2,3‐dihydro‐[3,4]‐cyclopentano‐1,2,4‐benzothiadiazine‐1,1‐dioxide (S 18986) [once daily (o.d.) administration of 1 mg/kg for 3 days...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2007-08, Vol.21 (4), p.349-354
Hauptverfasser:	Bertaina-Anglade, V., Drieu la Rochelle, C., Muñoz, C., Morain, P., Bernard, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation AMPA modulator Animals Benzothiadiazines - administration & dosage Benzothiadiazines - pharmacology Biological and medical sciences cognitive enhancer Dose-Response Relationship, Drug Drug Administration Schedule Exploratory Behavior - drug effects Male Medical sciences Memory - drug effects Nootropic Agents - administration & dosage Nootropic Agents - pharmacology object recognition task Pharmacology. Drug treatments Psychomotor Performance - drug effects Rats Rats, Sprague-Dawley Receptors, AMPA - drug effects S 18986 Time Factors
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Zusammenfassung:	The present study aimed at defining the best scheme of administration of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor‐positive modulator (S)‐2,3‐dihydro‐[3,4]‐cyclopentano‐1,2,4‐benzothiadiazine‐1,1‐dioxide (S 18986) [once daily (o.d.) administration of 1 mg/kg for 3 days vs. three times daily (t.i.d.) administration of 0.3 mg/kg for 3 days] to get an optimal procognitive activity in the object recognition task in rats. Memory performance [Recognition Index (RI)] of rats was significantly improved 1 h (RI = 41%, P
ISSN:	0767-3981 1472-8206
DOI:	10.1111/j.1472-8206.2007.00487.x