Chemical site-selective prenylation of proteins

A direct thionation procedure allows conversion of allylic alcohols into the corresponding thiols, the products of which are immediately compatible with one-pot site-selective selenenyl sulfide mediated protein conjugation.

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular bioSystems 2008-01, Vol.4 (6), p.558-561
Hauptverfasser:	Gamblin, David P, van Kasteren, Sander, Bernardes, Gonçalo J L, Chalker, Justin M, Oldham, Neil J, Fairbanks, Antony J, Davis, Benjamin G
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus - enzymology Binding Sites Hydrophobic and Hydrophilic Interactions Molecular Structure Propanols - chemistry Protein Prenylation Recombinant Proteins - chemical synthesis Recombinant Proteins - chemistry Selenium Compounds - chemistry Spectrometry, Mass, Electrospray Ionization - methods Subtilisin - chemical synthesis Subtilisin - chemistry Sulfhydryl Compounds - chemical synthesis Sulfhydryl Compounds - chemistry
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Beschreibung
Zusammenfassung:	A direct thionation procedure allows conversion of allylic alcohols into the corresponding thiols, the products of which are immediately compatible with one-pot site-selective selenenyl sulfide mediated protein conjugation.
ISSN:	1742-206X 1742-2051
DOI:	10.1039/b802199f