Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing

Multi-locus sequencing data for 242 different isolates of Candida tropicalis generated a dendrogram showing 235 strains assigned to a single large recently evolved group which contained several small clonal clusters. Haplotype analysis of a representative strain subset revealed a high level of recom...

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Veröffentlicht in:	Fungal genetics and biology 2008-06, Vol.45 (6), p.1040-1042
Hauptverfasser:	Jacobsen, Mette D., Davidson, Amanda D., Li, Shu-Ying, Shaw, Duncan J., Gow, Neil A.R., Odds, Frank C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Candida albicans - genetics Candida tropicalis Candida tropicalis - classification Candida tropicalis - genetics Candida tropicalis - isolation & purification Candidiasis - microbiology Haplotypes Humans MLST Mycological Typing Techniques Phylogenetics Phylogeny Polymorphism, Single Nucleotide Recombination, Genetic
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Beschreibung
Zusammenfassung:	Multi-locus sequencing data for 242 different isolates of Candida tropicalis generated a dendrogram showing 235 strains assigned to a single large recently evolved group which contained several small clonal clusters. Haplotype analysis of a representative strain subset revealed a high level of recombination events in an otherwise clonal population. Pairs of isolates from single sources showed non-identity attributable to loss of heterozygosity in some genes in a manner similar to that established for C. albicans.
ISSN:	1087-1845 1096-0937
DOI:	10.1016/j.fgb.2008.03.011