Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic

A mimic of a (1→2),(1→6)-mannotrioside was synthesized by replacing the central mannose unit with an enantiomerically pure, conformationally stable trans-diaxial cyclohexanediol. The three-dimensional structure of the molecule was investigated by NMR spectroscopy supported by molecular modelling and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Carbohydrate research 2007-09, Vol.342 (12-13), p.1859-1868
Hauptverfasser:	Mari, Silvia, Sánchez-Medina, Inmaculada, Mereghetti, Pierangelo, Belvisi, Laura, Jiménez-Barbero, Jesus, Bernardi, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry Carbohydrate Conformation Carbohydrate mimics Carbohydrate Sequence Conformational analysis Glycomimetics Indicators and Reagents Magnetic Resonance Spectroscopy Mannosides - chemistry Mannotrioside Models, Molecular Molecular Sequence Data Trisaccharides - chemical synthesis Trisaccharides - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A mimic of a (1→2),(1→6)-mannotrioside was synthesized by replacing the central mannose unit with an enantiomerically pure, conformationally stable trans-diaxial cyclohexanediol. The three-dimensional structure of the molecule was investigated by NMR spectroscopy supported by molecular modelling and was compared to the known features of the natural mannotrioside.
ISSN:	0008-6215 1873-426X
DOI:	10.1016/j.carres.2007.03.019