Determination of α-hydroxy acids in cosmetic products by capillary electrophoresis
In this work, a simple and reliable method for the simultaneous analysis of α-hydroxy acids such as tartaric, glycolic and lactic acids in cosmetic products was developed using capillary electrophoresis with indirect UV detection at 254 nm. A buffer solution containing 10 mmol l −1 potassium phthala...
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Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2006-02, Vol.40 (2), p.242-248 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | In this work, a simple and reliable method for the simultaneous analysis of α-hydroxy acids such as tartaric, glycolic and lactic acids in cosmetic products was developed using capillary electrophoresis with indirect UV detection at 254
nm. A buffer solution containing 10
mmol
l
−1 potassium phthalate (pH 4.1) and 0.5
mmol
l
−1 cetyltrimethylammonium bromide as electroosmotic flow modifier allowed baseline resolution of the analytes in approximately 3
min. A few validation parameters of the proposed method include: good linearity for all compounds in the range from 10 to 100
mg
l
−1 with coefficients of correlation larger than 0.9999. The average recoveries of tartaric, glycolic and lactic acids in commercial samples were 99.12, 99.41 and 99.43%, respectively. The method presented acceptable precision with average relative standard deviation of 0.54% (assay of commercial samples), 0.44% (peak area) and 0.16% (migration time). |
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ISSN: | 0731-7085 1873-264X |
DOI: | 10.1016/j.jpba.2005.07.009 |