Palladium-Catalyzed Intramolecular N-Arylation of Heteroarenes: A Novel and Efficient Route to Benzimidazo[1,2-a]quinolines

An efficient new route for the synthesis of benzimidazo[1,2-a]quinolines has been developed via the palladium-catalyzed intramolecular Buchwald−Harwtig aryl amination of newly synthesized 2-(2‘-bromoanilino)quinolines.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2006-02, Vol.71 (3), p.1280-1283
Hauptverfasser:	Venkatesh, C, Sundaram, G. S. M, Ila, H, Junjappa, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Catalysis Chemistry Cyclization Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Isoquinolines - chemical synthesis Isoquinolines - chemistry Ligands Molecular Structure Organic chemistry Palladium - chemistry Preparations and properties Solvents Temperature
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Beschreibung
Zusammenfassung:	An efficient new route for the synthesis of benzimidazo[1,2-a]quinolines has been developed via the palladium-catalyzed intramolecular Buchwald−Harwtig aryl amination of newly synthesized 2-(2‘-bromoanilino)quinolines.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo0522411