5,6:8,9-Diepoxy and Other Cytotoxic Sterols from the Marine Sponge Homaxinella sp

Four new (1, 2, 4, and 5) and 14 known (3 and 6−18) polyoxygenated sterols have been isolated from the MeOH extract of the marine sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures of the sterols were established by 1D and 2D NMR and MS spectroscopic analysis. 5,6:8,9-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-01, Vol.69 (1), p.131-134
Hauptverfasser:	Mansoor, Tayyab A, Lee, Yoon Mi, Hong, Jongki, Lee, Chong-O, Im, Kwang Sik, Jung, Jee H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticarcinogenic activity Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences chemical structure cultured cells cytotoxicity Drug Screening Assays, Antitumor General pharmacology Homaxinella Humans Korea Marine Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera Porifera - chemistry spectral analysis sterols Sterols - chemistry Sterols - isolation & purification Sterols - pharmacology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Four new (1, 2, 4, and 5) and 14 known (3 and 6−18) polyoxygenated sterols have been isolated from the MeOH extract of the marine sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures of the sterols were established by 1D and 2D NMR and MS spectroscopic analysis. 5,6:8,9-Diepoxy sterols (1−3) were isolated from a marine organism for the first time. The isolated sterols were tested against a panel of five human solid tumor cell lines and exhibited varying degrees of cytotoxicity.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0502950