Another niche for Notch

Another niche for Notch

The Notch signaling pathway patterns the developing nephron along the proximal–distal axis during renal development. In an adult acute tubular necrosis model, Kobayashi et al. now show expression of many Notch components and the activation of Notch target genes, suggesting a critical function for No...

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Veröffentlicht in:Kidney international 2008-06, Vol.73 (11), p.1207-1209
1. Verfasser: Dressler, G.R.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Gene Expression Regulation, Developmental
Humans
Kidney Tubules - growth & development
Kidney Tubules - physiology
Receptors, Notch - metabolism
Regeneration
Signal Transduction
Transcriptional Activation
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Beschreibung
Zusammenfassung:The Notch signaling pathway patterns the developing nephron along the proximal–distal axis during renal development. In an adult acute tubular necrosis model, Kobayashi et al. now show expression of many Notch components and the activation of Notch target genes, suggesting a critical function for Notch in regenerating proximal tubules.
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.2008.39