Enhanced food intake regulatory responses after a glucose drink in hyperinsulinemic men

Objective: To determine the effect of hyperinsulinemia on food intake and plasma concentrations of glucose and food intake regulatory hormones in men after a glucose drink. Design: Cross-sectional clinical intervention study of the effect of a glucose drink on food intake regulation. Subjects: Thirty-three normoinsulinemic (NI) (body mass index (BMI) = 25.3 +/- 0.6; age = 41.4 +/- 2.4) and 32 hyperinsulinemic (HI) men (BMI = 29.5 +/- 0.6; age = 43.4 +/- 2.6). Measurements: Food intake was measured from a pizza meal 1 h after subjects consumed either a noncaloric sweetened drink or a glucose-containing drink (75g/300 ml) in random order on two occasions. On another occasion, blood samples were taken every 30 min for 2 h after the glucose drink. Results: Fasting insulin in the HI and NI men was 65 +/- 3 (mean +/- s.e.m.) and 26 +/- 1.5 pmol/l, respectively. Food intake at the pizza meal was reduced by the glucose drink (P