Immune suppression by tumor-specific CD4 + regulatory T-cells in cancer
Regulatory T-cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Recent studies demonstrate the existence of CD4 + regulatory T-cells at tumor sites, implying that these Tr...
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Veröffentlicht in: | Seminars in cancer biology 2006-02, Vol.16 (1), p.73-79 |
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Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Regulatory T-cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Recent studies demonstrate the existence of CD4
+ regulatory T-cells at tumor sites, implying that these Treg cells may induce antigen-specific and local immune tolerance. This review will discuss the natural ligands and their potential roles of tumor-specific CD4
+ regulatory T-cells in cancer therapy. |
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ISSN: | 1044-579X 1096-3650 |
DOI: | 10.1016/j.semcancer.2005.07.009 |