A Prospective Study of Lycopene and Tomato Product Intake and Risk of Prostate Cancer
Background: Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this possible association. Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in the Prostate, Lung, Colorectal,...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2006-01, Vol.15 (1), p.92-98 |
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| creator | KIRSH, Victoria A MAYNE, Susan T PETERS, Ulrike CHATTERJEE, Nilanjan LEITZMANN, Michael F DIXON, L. Beth URBAN, Donald A CRAWFORD, E. David HAYES, Richard B |
| description | Background: Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this
possible association.
Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in
the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early
detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency
questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of
4.2 years of follow-up.
Results: Lycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato
servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate
cancer: relative risk (RR), 0.83; 95% confidence interval (95% CI), 0.67-1.03 for ≥1 serving/wk versus < 0.5 serving/mo; P trend = 0.06 and advanced prostate cancer: RR, 0.79; 95% CI, 0.56-1.10; P trend = 0.12] and spaghetti/tomato sauce consumption (advanced prostate cancer: RR = 0.81, 95% CI, 0.57-1.16 for ≥2 servings/wk
versus < 1 serving/mo; P trend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of
lycopene ( P trend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P trend = 0.12; pizza, P trend = 0.15; lasagna, P trend = 0.02).
Conclusions: This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from
prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further
corroboration. (Cancer Epidemiol Biomarkers Prev 2006;15(1):92–8) |
| doi_str_mv | 10.1158/1055-9965.EPI-05-0563 |
| format | Article |
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possible association.
Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in
the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early
detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency
questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of
4.2 years of follow-up.
Results: Lycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato
servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate
cancer: relative risk (RR), 0.83; 95% confidence interval (95% CI), 0.67-1.03 for ≥1 serving/wk versus < 0.5 serving/mo; P trend = 0.06 and advanced prostate cancer: RR, 0.79; 95% CI, 0.56-1.10; P trend = 0.12] and spaghetti/tomato sauce consumption (advanced prostate cancer: RR = 0.81, 95% CI, 0.57-1.16 for ≥2 servings/wk
versus < 1 serving/mo; P trend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of
lycopene ( P trend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P trend = 0.12; pizza, P trend = 0.15; lasagna, P trend = 0.02).
Conclusions: This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from
prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further
corroboration. (Cancer Epidemiol Biomarkers Prev 2006;15(1):92–8)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-05-0563</identifier><identifier>PMID: 16434593</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Aged ; Anticarcinogenic Agents - administration & dosage ; Antioxidants - administration & dosage ; Biological and medical sciences ; Carotenoids - administration & dosage ; cohort study ; Diet ; Genetic Predisposition to Disease ; Humans ; lycopene ; Lycopersicon esculentum ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Nephrology. Urinary tract diseases ; Proportional Hazards Models ; Prospective Studies ; prostate cancer ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - prevention & control ; Risk Assessment ; tomatoes ; Tumors ; Tumors of the urinary system ; United States ; Urinary tract. Prostate gland</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2006-01, Vol.15 (1), p.92-98</ispartof><rights>2006 INIST-CNRS</rights><rights>(Cancer Epidemiol Biomarkers Prev 2006;15(1):92-8).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-4cb496342018613fe9153292971439d8fb83b47f1ceefc1066b16e707276182c3</citedby><cites>FETCH-LOGICAL-c533t-4cb496342018613fe9153292971439d8fb83b47f1ceefc1066b16e707276182c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17603331$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16434593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIRSH, Victoria A</creatorcontrib><creatorcontrib>MAYNE, Susan T</creatorcontrib><creatorcontrib>PETERS, Ulrike</creatorcontrib><creatorcontrib>CHATTERJEE, Nilanjan</creatorcontrib><creatorcontrib>LEITZMANN, Michael F</creatorcontrib><creatorcontrib>DIXON, L. Beth</creatorcontrib><creatorcontrib>URBAN, Donald A</creatorcontrib><creatorcontrib>CRAWFORD, E. David</creatorcontrib><creatorcontrib>HAYES, Richard B</creatorcontrib><title>A Prospective Study of Lycopene and Tomato Product Intake and Risk of Prostate Cancer</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Background: Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this
possible association.
Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in
the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early
detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency
questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of
4.2 years of follow-up.
Results: Lycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato
servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate
cancer: relative risk (RR), 0.83; 95% confidence interval (95% CI), 0.67-1.03 for ≥1 serving/wk versus < 0.5 serving/mo; P trend = 0.06 and advanced prostate cancer: RR, 0.79; 95% CI, 0.56-1.10; P trend = 0.12] and spaghetti/tomato sauce consumption (advanced prostate cancer: RR = 0.81, 95% CI, 0.57-1.16 for ≥2 servings/wk
versus < 1 serving/mo; P trend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of
lycopene ( P trend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P trend = 0.12; pizza, P trend = 0.15; lasagna, P trend = 0.02).
Conclusions: This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from
prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further
corroboration. (Cancer Epidemiol Biomarkers Prev 2006;15(1):92–8)</description><subject>Aged</subject><subject>Anticarcinogenic Agents - administration & dosage</subject><subject>Antioxidants - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - administration & dosage</subject><subject>cohort study</subject><subject>Diet</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>lycopene</subject><subject>Lycopersicon esculentum</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>prostate cancer</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - prevention & control</subject><subject>Risk Assessment</subject><subject>tomatoes</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>United States</subject><subject>Urinary tract. Prostate gland</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LwzAUhoMofkx_gtIbvavmNE3SXMrwYzBw-HEd0vTUVbd2Jqmyf2_qJoPACeQ5J-95CDkHeg3AixugnKdKCX59N5uklMcj2B45Bs6KVErO9-P9nzkiJ95_UEql4vyQHIHIWc4VOyZvt8nMdX6FNjTfmLyEvlonXZ1M17ZbYYuJaavktVua0A1g1duQTNpgPjcvz43_HPBhRjABk7FpLbpTclCbhcezbR2Rt_u71_FjOn16mIxvp6nljIU0t2WuBMszCoUAVqOK6TOVKQk5U1VRlwUrc1mDRawtUCFKECipzKSAIrNsRK42c1eu--rRB71svMXFwrTY9V4PaMYzFkG-AW0M6h3WeuWapXFrDVQPPvXgSg-udPSpKdeDz9h3sf2gL5dY7bq2AiNwuQWMt2ZRu7h_43ecFJQxBruk8-Z9_tM41PbPlEOPxtm5Bq5Bq4z9ApKjiZc</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>KIRSH, Victoria A</creator><creator>MAYNE, Susan T</creator><creator>PETERS, Ulrike</creator><creator>CHATTERJEE, Nilanjan</creator><creator>LEITZMANN, Michael F</creator><creator>DIXON, L. Beth</creator><creator>URBAN, Donald A</creator><creator>CRAWFORD, E. David</creator><creator>HAYES, Richard B</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>A Prospective Study of Lycopene and Tomato Product Intake and Risk of Prostate Cancer</title><author>KIRSH, Victoria A ; MAYNE, Susan T ; PETERS, Ulrike ; CHATTERJEE, Nilanjan ; LEITZMANN, Michael F ; DIXON, L. Beth ; URBAN, Donald A ; CRAWFORD, E. David ; HAYES, Richard B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-4cb496342018613fe9153292971439d8fb83b47f1ceefc1066b16e707276182c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Anticarcinogenic Agents - administration & dosage</topic><topic>Antioxidants - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - administration & dosage</topic><topic>cohort study</topic><topic>Diet</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>lycopene</topic><topic>Lycopersicon esculentum</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>prostate cancer</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - prevention & control</topic><topic>Risk Assessment</topic><topic>tomatoes</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>United States</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIRSH, Victoria A</creatorcontrib><creatorcontrib>MAYNE, Susan T</creatorcontrib><creatorcontrib>PETERS, Ulrike</creatorcontrib><creatorcontrib>CHATTERJEE, Nilanjan</creatorcontrib><creatorcontrib>LEITZMANN, Michael F</creatorcontrib><creatorcontrib>DIXON, L. Beth</creatorcontrib><creatorcontrib>URBAN, Donald A</creatorcontrib><creatorcontrib>CRAWFORD, E. David</creatorcontrib><creatorcontrib>HAYES, Richard B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIRSH, Victoria A</au><au>MAYNE, Susan T</au><au>PETERS, Ulrike</au><au>CHATTERJEE, Nilanjan</au><au>LEITZMANN, Michael F</au><au>DIXON, L. Beth</au><au>URBAN, Donald A</au><au>CRAWFORD, E. David</au><au>HAYES, Richard B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Prospective Study of Lycopene and Tomato Product Intake and Risk of Prostate Cancer</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>15</volume><issue>1</issue><spage>92</spage><epage>98</epage><pages>92-98</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Background: Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this
possible association.
Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in
the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early
detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency
questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of
4.2 years of follow-up.
Results: Lycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato
servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate
cancer: relative risk (RR), 0.83; 95% confidence interval (95% CI), 0.67-1.03 for ≥1 serving/wk versus < 0.5 serving/mo; P trend = 0.06 and advanced prostate cancer: RR, 0.79; 95% CI, 0.56-1.10; P trend = 0.12] and spaghetti/tomato sauce consumption (advanced prostate cancer: RR = 0.81, 95% CI, 0.57-1.16 for ≥2 servings/wk
versus < 1 serving/mo; P trend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of
lycopene ( P trend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P trend = 0.12; pizza, P trend = 0.15; lasagna, P trend = 0.02).
Conclusions: This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from
prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further
corroboration. (Cancer Epidemiol Biomarkers Prev 2006;15(1):92–8)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>16434593</pmid><doi>10.1158/1055-9965.EPI-05-0563</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Anticarcinogenic Agents - administration & dosage Antioxidants - administration & dosage Biological and medical sciences Carotenoids - administration & dosage cohort study Diet Genetic Predisposition to Disease Humans lycopene Lycopersicon esculentum Male Medical sciences Middle Aged Multivariate Analysis Nephrology. Urinary tract diseases Proportional Hazards Models Prospective Studies prostate cancer Prostatic Neoplasms - epidemiology Prostatic Neoplasms - prevention & control Risk Assessment tomatoes Tumors Tumors of the urinary system United States Urinary tract. Prostate gland |
| title | A Prospective Study of Lycopene and Tomato Product Intake and Risk of Prostate Cancer |
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