effect of MTHFR(C677T) genotype on plasma homocysteine concentrations in healthy children is influenced by gender

Objective: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. Design: Cross-sectional study by face-to-face intervi...

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Veröffentlicht in:	European journal of clinical nutrition 2006-02, Vol.60 (2), p.155-162
Hauptverfasser:	Papoutsakis, C, Yiannakouris, N, Manios, Y, Papaconstantinou, E, Magkos, F, Schulpis, K.H, Zampelas, A, Matalas, A.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance anthropometric measurements Biological and medical sciences boys Child child nutrition Children Children & youth Clinical Nutrition Consumption Cross-Sectional Studies Diet Dietary intake dietary surveys Enzymes Epidemiology Female Folic acid Folic Acid - blood Food intake Gender gender differences Gene polymorphism genetic polymorphism Genotype Genotype & phenotype Genotypes girls Greece Homocysteine Homocysteine - blood Humans Internal Medicine Male Males Medical sciences Medicine Medicine & Public Health Mental Recall Metabolic Diseases Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics nutrient intake Nutrition nutrition-genotype interaction nutritional status original-article Plasma Polymorphism Polymorphism, Single Nucleotide Public Health Reductases school children Schools Sex Factors Vitamin B Vitamin B 12 - blood Vitamin B12
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Zusammenfassung:	Objective: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. Design: Cross-sectional study by face-to-face interview. Setting and subjects: A total of 186 sixth-grade students participated from twelve randomly selected primary schools in Volos, Greece. Methods: Fasting tHcy, folate, and vitamin B₁₂ were measured in plasma. The MTHFR genotypes were determined. Anthropometric and dietary intake data by 24-h recall were collected. Results: Geometric means for plasma tHcy, plasma folate and energy-adjusted dietary folate did not differ between females and males. The homozygous mutant TT genotype was associated with higher tHcy only in children with lower plasma folate concentrations (
ISSN:	0954-3007 1476-5640
DOI:	10.1038/sj.ejcn.1602280