Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives

Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives

Previous work suggests that impairments in executive function and verbal memory in particular may persist in euthymic bipolar patients and serve as an indicator of genetic risk (endophenotype). A systematic review of the literature was undertaken. Effects sizes were extracted from selected papers an...

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Veröffentlicht in:Psychological medicine 2008-06, Vol.38 (6), p.771-785
Hauptverfasser: Arts, B., Jabben, N., Krabbendam, L., van Os, J.
Format: Artikel
Sprache:eng
Schlagworte:
Adult and adolescent clinical studies
Affect
Attention
Biological and medical sciences
Bipolar affective disorder
Bipolar disorder
Bipolar Disorder - diagnosis
Bipolar Disorder - genetics
Bipolar Disorder - psychology
Bipolar disorders
Bipolar patients
Cognition
Cognition Disorders - diagnosis
Cognition Disorders - genetics
Cognition Disorders - psychology
Cognitive ability
Concept Formation
Data analysis
English language
Executive function
Genetic testing
Humans
Medical sciences
Memory, Short-Term
Meta-analysis
Mood disorders
Neural networks
Patients
Phenotype
Problem Solving
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reaction Time
Relatives
Sample size
Schizophrenia
Standard deviation
Studies
Systematic review
Verbal Learning
Verbal memory
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Beschreibung
Zusammenfassung:Previous work suggests that impairments in executive function and verbal memory in particular may persist in euthymic bipolar patients and serve as an indicator of genetic risk (endophenotype). A systematic review of the literature was undertaken. Effects sizes were extracted from selected papers and pooled using meta-analytical techniques. In bipolar patients, large effect sizes (d>0.8) were noted for executive functions (working memory, executive control, fluency) and verbal memory. Medium effect sizes (0.5
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291707001675