Charge selective function in childhood glomerular diseases

The charge selectivity (CS) function in human renal disease has not been unequivocally demonstrated to date. However, the clearance ratio of IgA to IgG may be theoretically useful in estimating CS in humans, since IgA and IgG have similar sizes and tertiary structures, but distinct isoelectric point...

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Veröffentlicht in:	Pediatric research 2006-02, Vol.59 (2), p.336-340
Hauptverfasser:	TAKAHASHI, Shori, WATANABE, Saori, WADA, Naohiro, MURAKAMI, Hitohiko, FUNAKI, Satoshi, YAN, Kunimasa, KONDO, Yoshiaki, HARADA, Kensuke, NAGATA, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Child Child, Preschool General aspects Glomerulonephritis Humans Infant Kidney Diseases - physiopathology Kidney Glomerulus - pathology Kidney Glomerulus - physiopathology Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure
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Zusammenfassung:	The charge selectivity (CS) function in human renal disease has not been unequivocally demonstrated to date. However, the clearance ratio of IgA to IgG may be theoretically useful in estimating CS in humans, since IgA and IgG have similar sizes and tertiary structures, but distinct isoelectric points (3.5-5.5 [IgA] and 4.5-9.0 [IgG]), and Stokes-Einstein radius: 61 A (IgA) and 49-60 A (IgG). Two-dimensional electrophoresis with the following immunoblotting revealed that the considerably anionic portion (isoelectric points [pI]
ISSN:	0031-3998 1530-0447
DOI:	10.1203/01.pdr.0000196733.47083.81