Stereochemistry of Pladienolide B

Stereochemistry of Pladienolide B

Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of...

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Veröffentlicht in:Journal of antibiotics 2007-06, Vol.60 (6), p.364-369
Hauptverfasser: Asai, Naoki, Kotake, Yoshihiko, Niijima, Jun, Fukuda, Yoshio, Uehara, Taisuke, Sakai, Takashi
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - chemistry
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Epoxy Compounds - chemistry
Life Sciences
Macrolides - chemistry
Medicinal Chemistry
Microbiology
Models, Molecular
Molecular Conformation
Nuclear Magnetic Resonance, Biomolecular
Organic Chemistry
original-article
Spectrometry, Mass, Electrospray Ionization
Stereoisomerism
Streptomyces - chemistry
Streptomyces platensis
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Beschreibung
Zusammenfassung:Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2007.49