Impact of Body Mass Index on Platelet Aggregation After Administration of a High Loading Dose of 600 mg of Clopidogrel Before Percutaneous Coronary Intervention

Impact of Body Mass Index on Platelet Aggregation After Administration of a High Loading Dose of 600 mg of Clopidogrel Before Percutaneous Coronary Intervention

This study assessed the effect of body mass index (BMI) on platelet aggregation after administration of a high loading dose of clopidogrel 600 mg. Blood samples of 402 patients before percutaneous coronary intervention were collected ≥2 hours after administration of clopidogrel 600 mg. Platelet aggr...

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Veröffentlicht in:The American journal of cardiology 2007-07, Vol.100 (2), p.203-205
Hauptverfasser: Sibbing, Dirk, MD, von Beckerath, Olga, MD, Schömig, Albert, MD, Kastrati, Adnan, MD, von Beckerath, Nicolas, MD
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Diphosphate - pharmacology
Aged
Angioplasty, Balloon, Coronary
Biological and medical sciences
Body Mass Index
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Coronary heart disease
Diseases of the cardiovascular system
Drug dosages
Drug therapy
Female
Heart
Humans
Male
Medical sciences
Multivariate Analysis
Platelet Aggregation - drug effects
Platelet Aggregation - physiology
Platelet Aggregation Inhibitors - administration & dosage
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Ticlopidine - administration & dosage
Ticlopidine - analogs & derivatives
Weight
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Beschreibung
Zusammenfassung:This study assessed the effect of body mass index (BMI) on platelet aggregation after administration of a high loading dose of clopidogrel 600 mg. Blood samples of 402 patients before percutaneous coronary intervention were collected ≥2 hours after administration of clopidogrel 600 mg. Platelet aggregation was measured in response to adenosine diphosphate (ADP; 5 and 20 μM). Patients were categorized as normal weight (BMI
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2007.02.081