Antimicrobial β-peptoids by a block synthesis approach

Antimicrobial peptides and their mimetics offer a potential new disinfective tool. β-Peptoids (oligo- N-substituted β-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-β-peptoids were first prepared and then ligated via amide bond formation...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-03, Vol.16 (5), p.1245-1248
Hauptverfasser:	Shuey, Steven W., Delaney, William J., Shah, Mukesh C., Scialdone, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial Biological and medical sciences Escherichia coli - drug effects Medical sciences Molecular Structure Peptide mimetic Peptoids - chemical synthesis Peptoids - chemistry Peptoids - pharmacology Pharmacology. Drug treatments β-Peptoid
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Beschreibung
Zusammenfassung:	Antimicrobial peptides and their mimetics offer a potential new disinfective tool. β-Peptoids (oligo- N-substituted β-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-β-peptoids were first prepared and then ligated via amide bond formation to synthesize larger β-peptoids was developed. The β-peptoids were found to possess moderate activity in an Escheridchia coli assay.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.11.075