Solubilization of docetaxel in poly(ethylene oxide ) -block-poly (butylene /styrene oxide) micelles

Poly(ethylene oxide)-block-poly(styrene oxide) (PEO-b-PSO) and PEO-b-poly(butylene oxide) (PEO-b-PBO) of different chain lengths were synthesized and characterized for their self-assembling properties in water by dynamic/static light scattering, spectrofluorimetry, and transmission electron microsco...

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Veröffentlicht in:	Biomacromolecules 2007-07, Vol.8 (7), p.2250-2257
Hauptverfasser:	ELSABAHY, Mahmoud, PERRON, Marie-Eve, BERTRAND, Nicolas, YU, Ga-Er, LEROUX, Jean-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biological and medical sciences Docetaxel Epoxy Compounds - chemistry Exact sciences and technology General pharmacology Medical sciences Micelles Microscopy, Electron, Transmission Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polyenes - chemistry Polyethylene Glycols - chemistry Properties and characterization Solubility Solution and gel properties Taxoids - chemistry
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Beschreibung
Zusammenfassung:	Poly(ethylene oxide)-block-poly(styrene oxide) (PEO-b-PSO) and PEO-b-poly(butylene oxide) (PEO-b-PBO) of different chain lengths were synthesized and characterized for their self-assembling properties in water by dynamic/static light scattering, spectrofluorimetry, and transmission electron microscopy. The resulting polymeric micelles were evaluated for their ability to solubilize and protect the anticancer drug docetaxel (DCTX) from degradation. The drug release kinetics as well as the cytotoxicity of the loaded micelles were assessed in vitro. All polymers formed micelles with a highly viscous core at low critical association concentrations (
ISSN:	1525-7797 1526-4602
DOI:	10.1021/bm070226v