Current role of LC-MS in therapeutic drug monitoring

The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2007-08, Vol.388 (7), p.1327-1349
Hauptverfasser:	Saint-Marcoux, Franck, Sauvage, François-Ludovic, Marquet, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Liquid Drug Monitoring - methods Humans liquid chromatography Mass Spectrometry Pharmaceutical Preparations - analysis Therapeutic drug monitoring
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Beschreibung
Zusammenfassung:	The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring: immunosuppressants, antifungal drugs, antiretroviral drugs, antidepressants and antipsychotics. For each class of compounds, we focussed on the most interesting methods and evaluated the current role of LC-MS in therapeutic drug monitoring.
ISSN:	1618-2642 1618-2650
DOI:	10.1007/s00216-007-1320-1