Antisperm antibodies and conception

Antisperm antibodies and conception

Sperm have been known to be antigenic for more than a century. There is a strong body of evidence that in humans and in other species at least some antibodies that bind to sperm antigens can cause infertility. Therefore, these antibodies are of interest today for two practical reasons. Firstly, the...

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Veröffentlicht in:Seminars in immunopathology 2007-06, Vol.29 (2), p.169-184
Hauptverfasser: Chamley, L W, Clarke, G N
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Antigens
Autoantibodies - blood
Autoantibodies - immunology
Cervix
Contraception, Immunologic
Female
Females
Feral populations
Fertility
Fertilization - immunology
Humans
Immune system
Infertility
Infertility, Female - etiology
Infertility, Female - immunology
Infertility, Male - immunology
Leukocytes
Lymphocytes
Male
Puberty
Sperm
Spermatogenesis
Spermatozoa - drug effects
Spermatozoa - immunology
Vaccines
Vasectomy
Women
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Beschreibung
Zusammenfassung:Sperm have been known to be antigenic for more than a century. There is a strong body of evidence that in humans and in other species at least some antibodies that bind to sperm antigens can cause infertility. Therefore, these antibodies are of interest today for two practical reasons. Firstly, the association of the antibodies with infertility means that they must be detected and then the couples treated appropriately. Secondly, because these antibodies can induce infertility they have the potential to be developed for contraceptive purposes in humans and also for the control of feral animal populations.
ISSN:1863-2297
1863-2300
DOI:10.1007/s00281-007-0075-2