Striatal D2 receptor binding as a marker of prognosis and outcome in untreated first-episode psychosis

In a preliminary 123I-IBZM SPECT study in first-episode psychosis, a relationship between striatal dopaminergic D2 receptor (D2R) binding and premorbid adjustment was suggested. These results were replicated in the present study ( n = 18), and D2R binding at diagnosis predicted a high probability fo...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2006-01, Vol.29 (2), p.662-666
Hauptverfasser: Corripio, Iluminada, Pérez, Víctor, Catafau, Ana M., Mena, Esther, Carrió, Ignasi, Alvarez, Enric
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Sprache:eng
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Zusammenfassung:In a preliminary 123I-IBZM SPECT study in first-episode psychosis, a relationship between striatal dopaminergic D2 receptor (D2R) binding and premorbid adjustment was suggested. These results were replicated in the present study ( n = 18), and D2R binding at diagnosis predicted a high probability for schizophrenia outcome by 2-year follow-up. The present findings contribute to the evidence of abnormal D2R binding in schizophrenia and suggest that SPECT might be useful for outcome prediction in first-episode psychosis.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2005.07.038