Highly Enantioselective Aryl Additions of [AlAr3(thf)] to Ketones Catalyzed by a Titanium(IV) Catalyst of (S)-Binol

Highly Enantioselective Aryl Additions of [AlAr3(thf)] to Ketones Catalyzed by a Titanium(IV) Catalyst of (S)-Binol

Chiral transfer: Novel asymmetric aryl transfers from [AlAr3(thf)] to a wide variety of ketones are catalyzed by an in situ generated titanium species with (S)‐binol as the chiral ligand. The reaction affords tertiary alcohols with enantioselectivities up to 97 % ee (see scheme). Binol=2,2′‐dihydrox...

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Veröffentlicht in:Angewandte Chemie International Edition 2007-01, Vol.46 (28), p.5373-5376
Hauptverfasser: Chen, Chien-An, Wu, Kuo-Hui, Gau, Han-Mou
Format: Artikel
Sprache:eng
Schlagworte:
aluminum
asymmetric synthesis
Catalysis
homogeneous catalysis
ketones
Ketones - chemical synthesis
Ketones - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Stereoisomerism
titanium
Titanium - chemistry
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Zusammenfassung:Chiral transfer: Novel asymmetric aryl transfers from [AlAr3(thf)] to a wide variety of ketones are catalyzed by an in situ generated titanium species with (S)‐binol as the chiral ligand. The reaction affords tertiary alcohols with enantioselectivities up to 97 % ee (see scheme). Binol=2,2′‐dihydroxy‐1,1′‐binaphthyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200701201