Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study
Summary Objective Overt or subclinical thyroid dysfunction is common within the community, yet the significance of subtle anomalies in thyroid function tests remains contentious. The aims of this study were to: (a) establish reference intervals for serum‐free thyroxine (FT4), thyroid‐stimulating ho...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2006-01, Vol.64 (1), p.97-104 |
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| creator | O'Leary, Peter C. Feddema, Peter H. Michelangeli, Valdo P. Leedman, Peter J. Chew, Gerard T. Knuiman, Matthew Kaye, Joey Walsh, John P. |
| description | Summary
Objective Overt or subclinical thyroid dysfunction is common within the community, yet the significance of subtle anomalies in thyroid function tests remains contentious. The aims of this study were to: (a) establish reference intervals for serum‐free thyroxine (FT4), thyroid‐stimulating hormone (TSH) and thyroid antibodies (antithyroperoxidase, TPOAb and antithyroglobulin, TgAb) in the Busselton community of south‐western Western Australia; and (b) determine the prevalence of thyroid hormone anomalies in this community.
Subjects and design In 1981, 2115 adults residing in Busselton participated in a cross‐sectional health survey that involved blood collection and a questionnaire on lifestyle and general health history.
Measurements Serum samples were analysed for FT4, TSH, TPOAb and TgAb by immunochemiluminescent assays.
Results Based on standard statistical approaches and using guidelines recommended by the National Academy of Clinical Biochemistry (NACB), reference intervals were derived for each analyte: 9–23 pmol/l for FT4, 0·4–4·0 mIU/l (TSH), |
| doi_str_mv | 10.1111/j.1365-2265.2005.02424.x |
| format | Article |
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Objective Overt or subclinical thyroid dysfunction is common within the community, yet the significance of subtle anomalies in thyroid function tests remains contentious. The aims of this study were to: (a) establish reference intervals for serum‐free thyroxine (FT4), thyroid‐stimulating hormone (TSH) and thyroid antibodies (antithyroperoxidase, TPOAb and antithyroglobulin, TgAb) in the Busselton community of south‐western Western Australia; and (b) determine the prevalence of thyroid hormone anomalies in this community.
Subjects and design In 1981, 2115 adults residing in Busselton participated in a cross‐sectional health survey that involved blood collection and a questionnaire on lifestyle and general health history.
Measurements Serum samples were analysed for FT4, TSH, TPOAb and TgAb by immunochemiluminescent assays.
Results Based on standard statistical approaches and using guidelines recommended by the National Academy of Clinical Biochemistry (NACB), reference intervals were derived for each analyte: 9–23 pmol/l for FT4, 0·4–4·0 mIU/l (TSH), < 35 KIU/l (TPOAb) and < 55 KIU/l (TgAb). The prevalence of elevated thyroid antibodies was 12·4% among subjects without a history of thyroid disease and is more common in women than in men. Elevated thyroid antibody levels were observed at both extremes of TSH abnormality, but were more commonly increased when TSH levels were above 4·0 mIU/l (63% subjects) than for those with TSH levels 0·4–4·0mIU/l (7·8% subjects).
Conclusions This study establishes the prevalence of antibodies to thyroperoxidase and thyroglobulin in a community‐based sample and reference intervals for free T4 and TSH. When the NACB decision limits are applied to older men or women, there is a markedly increased number with ‘elevated’ autoantibody levels compared to sex‐ and age‐specific reference intervals.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2005.02424.x</identifier><identifier>PMID: 16402936</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antibodies - blood ; Autoantibodies - blood ; Biological and medical sciences ; Cross-Sectional Studies ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Health Surveys ; Humans ; Iodide Peroxidase - immunology ; Life Style ; Male ; Medical sciences ; Middle Aged ; Reference Standards ; Reference Values ; Sex Factors ; Thyroid Function Tests ; Thyroid Gland - immunology ; Thyroid Hormones - blood ; Thyrotropin - blood ; Thyroxine - blood ; Vertebrates: endocrinology ; Western Australia</subject><ispartof>Clinical endocrinology (Oxford), 2006-01, Vol.64 (1), p.97-104</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Jan 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5284-8aa040e311de21e81d03bde4e8bdccee48a64a5301df391a42405bddd2bd60163</citedby><cites>FETCH-LOGICAL-c5284-8aa040e311de21e81d03bde4e8bdccee48a64a5301df391a42405bddd2bd60163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2005.02424.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2005.02424.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17474695$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16402936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Leary, Peter C.</creatorcontrib><creatorcontrib>Feddema, Peter H.</creatorcontrib><creatorcontrib>Michelangeli, Valdo P.</creatorcontrib><creatorcontrib>Leedman, Peter J.</creatorcontrib><creatorcontrib>Chew, Gerard T.</creatorcontrib><creatorcontrib>Knuiman, Matthew</creatorcontrib><creatorcontrib>Kaye, Joey</creatorcontrib><creatorcontrib>Walsh, John P.</creatorcontrib><title>Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective Overt or subclinical thyroid dysfunction is common within the community, yet the significance of subtle anomalies in thyroid function tests remains contentious. The aims of this study were to: (a) establish reference intervals for serum‐free thyroxine (FT4), thyroid‐stimulating hormone (TSH) and thyroid antibodies (antithyroperoxidase, TPOAb and antithyroglobulin, TgAb) in the Busselton community of south‐western Western Australia; and (b) determine the prevalence of thyroid hormone anomalies in this community.
Subjects and design In 1981, 2115 adults residing in Busselton participated in a cross‐sectional health survey that involved blood collection and a questionnaire on lifestyle and general health history.
Measurements Serum samples were analysed for FT4, TSH, TPOAb and TgAb by immunochemiluminescent assays.
Results Based on standard statistical approaches and using guidelines recommended by the National Academy of Clinical Biochemistry (NACB), reference intervals were derived for each analyte: 9–23 pmol/l for FT4, 0·4–4·0 mIU/l (TSH), < 35 KIU/l (TPOAb) and < 55 KIU/l (TgAb). The prevalence of elevated thyroid antibodies was 12·4% among subjects without a history of thyroid disease and is more common in women than in men. Elevated thyroid antibody levels were observed at both extremes of TSH abnormality, but were more commonly increased when TSH levels were above 4·0 mIU/l (63% subjects) than for those with TSH levels 0·4–4·0mIU/l (7·8% subjects).
Conclusions This study establishes the prevalence of antibodies to thyroperoxidase and thyroglobulin in a community‐based sample and reference intervals for free T4 and TSH. When the NACB decision limits are applied to older men or women, there is a markedly increased number with ‘elevated’ autoantibody levels compared to sex‐ and age‐specific reference intervals.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies - blood</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Iodide Peroxidase - immunology</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reference Standards</subject><subject>Reference Values</subject><subject>Sex Factors</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Gland - immunology</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Vertebrates: endocrinology</subject><subject>Western Australia</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhSMEokvhLyALCW4J49hxHCQOZWlL0aoIAeJoOfEs6yWJWztpN_--Dru0EicsWbbl7z3NzEsSQiGjcb3dZpSJIs1zUWQ5QJFBznOe7R4li_uPx8kCGEAKQvCj5FkIW4ikhPJpckQFh7xiYpFcX_Q3GAb7Sw_W9YG4NRk2k3fWkI3znesxEN2buAdbO2Pjs9YBDXE90aRxXTf2dpjIBnU7bEgY_Q1O76IHkg9jCNgOEfzrGIbRTM-TJ2vdBnxxOI-TH2en35ef0tWX84vlySptilzyVGoNHJBRajCnKKkBVhvkKGvTNIhcasF1wYCaNauojv1DURtj8toIoIIdJ2_2vlfeXY-xR9XZ0GDb6h7dGFQJQgpKqwi--gfcutH3sTZFKympBFZESO6hxrsQPK7Vlbed9pOioOZM1FbNo1fz6NWcifqTidpF6cuD_1h3aB6EhxAi8PoA6NDodu1139jwwJW85KKaa3i_525ti9N_F6CWp5fzLerTvd6GAXf3eu1_K1GyslA_L88V_3i2KuHrN_WZ3QFo6bgN</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>O'Leary, Peter C.</creator><creator>Feddema, Peter H.</creator><creator>Michelangeli, Valdo P.</creator><creator>Leedman, Peter J.</creator><creator>Chew, Gerard T.</creator><creator>Knuiman, Matthew</creator><creator>Kaye, Joey</creator><creator>Walsh, John P.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study</title><author>O'Leary, Peter C. ; Feddema, Peter H. ; Michelangeli, Valdo P. ; Leedman, Peter J. ; Chew, Gerard T. ; Knuiman, Matthew ; Kaye, Joey ; Walsh, John P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5284-8aa040e311de21e81d03bde4e8bdccee48a64a5301df391a42405bddd2bd60163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies - blood</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Iodide Peroxidase - immunology</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reference Standards</topic><topic>Reference Values</topic><topic>Sex Factors</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Gland - immunology</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Vertebrates: endocrinology</topic><topic>Western Australia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Leary, Peter C.</creatorcontrib><creatorcontrib>Feddema, Peter H.</creatorcontrib><creatorcontrib>Michelangeli, Valdo P.</creatorcontrib><creatorcontrib>Leedman, Peter J.</creatorcontrib><creatorcontrib>Chew, Gerard T.</creatorcontrib><creatorcontrib>Knuiman, Matthew</creatorcontrib><creatorcontrib>Kaye, Joey</creatorcontrib><creatorcontrib>Walsh, John P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Leary, Peter C.</au><au>Feddema, Peter H.</au><au>Michelangeli, Valdo P.</au><au>Leedman, Peter J.</au><au>Chew, Gerard T.</au><au>Knuiman, Matthew</au><au>Kaye, Joey</au><au>Walsh, John P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2006-01</date><risdate>2006</risdate><volume>64</volume><issue>1</issue><spage>97</spage><epage>104</epage><pages>97-104</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective Overt or subclinical thyroid dysfunction is common within the community, yet the significance of subtle anomalies in thyroid function tests remains contentious. The aims of this study were to: (a) establish reference intervals for serum‐free thyroxine (FT4), thyroid‐stimulating hormone (TSH) and thyroid antibodies (antithyroperoxidase, TPOAb and antithyroglobulin, TgAb) in the Busselton community of south‐western Western Australia; and (b) determine the prevalence of thyroid hormone anomalies in this community.
Subjects and design In 1981, 2115 adults residing in Busselton participated in a cross‐sectional health survey that involved blood collection and a questionnaire on lifestyle and general health history.
Measurements Serum samples were analysed for FT4, TSH, TPOAb and TgAb by immunochemiluminescent assays.
Results Based on standard statistical approaches and using guidelines recommended by the National Academy of Clinical Biochemistry (NACB), reference intervals were derived for each analyte: 9–23 pmol/l for FT4, 0·4–4·0 mIU/l (TSH), < 35 KIU/l (TPOAb) and < 55 KIU/l (TgAb). The prevalence of elevated thyroid antibodies was 12·4% among subjects without a history of thyroid disease and is more common in women than in men. Elevated thyroid antibody levels were observed at both extremes of TSH abnormality, but were more commonly increased when TSH levels were above 4·0 mIU/l (63% subjects) than for those with TSH levels 0·4–4·0mIU/l (7·8% subjects).
Conclusions This study establishes the prevalence of antibodies to thyroperoxidase and thyroglobulin in a community‐based sample and reference intervals for free T4 and TSH. When the NACB decision limits are applied to older men or women, there is a markedly increased number with ‘elevated’ autoantibody levels compared to sex‐ and age‐specific reference intervals.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16402936</pmid><doi>10.1111/j.1365-2265.2005.02424.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Antibodies - blood Autoantibodies - blood Biological and medical sciences Cross-Sectional Studies Endocrinopathies Female Fundamental and applied biological sciences. Psychology Health Surveys Humans Iodide Peroxidase - immunology Life Style Male Medical sciences Middle Aged Reference Standards Reference Values Sex Factors Thyroid Function Tests Thyroid Gland - immunology Thyroid Hormones - blood Thyrotropin - blood Thyroxine - blood Vertebrates: endocrinology Western Australia |
| title | Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study |
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