Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study

Summary Objective Overt or subclinical thyroid dysfunction is common within the community, yet the significance of subtle anomalies in thyroid function tests remains contentious. The aims of this study were to: (a) establish reference intervals for serum‐free thyroxine (FT4), thyroid‐stimulating hormone (TSH) and thyroid antibodies (antithyroperoxidase, TPOAb and antithyroglobulin, TgAb) in the Busselton community of south‐western Western Australia; and (b) determine the prevalence of thyroid hormone anomalies in this community. Subjects and design In 1981, 2115 adults residing in Busselton participated in a cross‐sectional health survey that involved blood collection and a questionnaire on lifestyle and general health history. Measurements Serum samples were analysed for FT4, TSH, TPOAb and TgAb by immunochemiluminescent assays. Results Based on standard statistical approaches and using guidelines recommended by the National Academy of Clinical Biochemistry (NACB), reference intervals were derived for each analyte: 9–23 pmol/l for FT4, 0·4–4·0 mIU/l (TSH),