$Activation of refractory T cell responses against hepatitis C virus core protein by ablation of interfering hydrophobic domains$

Activation of refractory T cell responses against hepatitis C virus core protein by ablation of interfering hydrophobic domains

Hepatitis C virus (HCV) is the major pathogen of chronic hepatitis and liver disease, but currently there are no prophylactic HCV vaccines available. The HCV core protein-encoding sequence is among the most conserved genes in the HCV genome, making it a prime candidate for a component of a vaccine....

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Veröffentlicht in:	Molecular therapy 2006-02, Vol.13 (2), p.338-346
Hauptverfasser:	Andersson, Helen A, Singh, Rana A K, Barry, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals CD8-Positive T-Lymphocytes - immunology Cell cycle Endoplasmic reticulum Female Gene therapy HeLa Cells Hepacivirus - genetics Hepacivirus - immunology Hepatitis C Hepatitis C - immunology Hepatitis C - prevention & control Hepatitis C Antigens - genetics Hepatitis C Antigens - immunology Hepatitis C virus Humans Hydrophobic and Hydrophilic Interactions Immunology Localization Lymphocyte Activation - immunology Lymphocytes Medical schools Medicine Mice Mice, Inbred BALB C Plasmids Proteasome Endopeptidase Complex - physiology Protein Structure, Tertiary - genetics Proteins Sequence Deletion - genetics Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Viral Core Proteins - antagonists & inhibitors Viral Core Proteins - genetics Viral Core Proteins - immunology Viral infections
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