Expression of neuromedins S and U and their receptors in the hypothalamus and endocrine glands of the rat
Neuromedin S (NMS) and neuromedin U (NMU) are regulatory peptides that share the C-terminal amino-acid sequence and act via common G protein-coupled receptors called NMUR1 and NMUR2. Semiquantitative real time-PCR showed that in the rat hypothalamus and testis NMS gene expression was markedly higher...
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Veröffentlicht in: | International journal of molecular medicine 2007-08, Vol.20 (2), p.255-259 |
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Zusammenfassung: | Neuromedin S (NMS) and neuromedin U (NMU) are regulatory peptides that
share the C-terminal amino-acid sequence and act via common G protein-coupled
receptors called NMUR1 and NMUR2. Semiquantitative real time-PCR showed that in
the rat hypothalamus and testis NMS gene expression was markedly higher than that
of the NMU gene, while the reverse occurred in the anterior pituitary and thyroid
gland. Low expression of both genes was detected in the thymus, adrenal gland
and ovary, whereas in the pancreatic islets only the expression of NMU mRNA was
detected. In the rat hypothalamus the expression of the NMUR2 gene was strikingly
higher than that of the NMUR1 gene; in contrast, in the testis and ovary the very
low expression of NMUR2 contrasted with the relatively high expression of the
NMUR1 gene. In the other glands examined only expression of the NMUR1 gene was
found. The marked differences in the level of expression of NMU, NMS and their
receptors in the hypothalamus and endocrine glands of the rat suggest that in
this species such neuromedins may play different roles in the functional regulation
of neuroendocrine axes. |
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ISSN: | 1107-3756 1791-244X |
DOI: | 10.3892/ijmm.20.2.255 |