Probing the stable G-quadruplex transition using quencher-free end-stacking ethynyl pyrene-adenosine

Probing the stable G-quadruplex transition using quencher-free end-stacking ethynyl pyrene-adenosine

Pyrene-modified adenosines in the dangling positions of G-rich oligodeoxynucleotides undergo pi-stacking in their G-quadruplex formation, but not in their single strands, which can be characterized by fluorescence lambda(max) changes that occur on stacking.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2007 (27), p.2817-2819
Hauptverfasser: Seo, Young Jun, Lee, Il Joon, Yi, Jeong Wu, Kim, Byeang Hyean
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine - chemistry
Base Sequence
Circular Dichroism
Oligonucleotides
Pyrenes - chemistry
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Zusammenfassung:Pyrene-modified adenosines in the dangling positions of G-rich oligodeoxynucleotides undergo pi-stacking in their G-quadruplex formation, but not in their single strands, which can be characterized by fluorescence lambda(max) changes that occur on stacking.
ISSN:1359-7345
1364-548X
DOI:10.1039/b707278c