Difluoromethylenediphosphonate:  A Convenient, Scalable, and High-Yielding Synthesis

Since the first disclosure of difluoromethylenediphosphonate, 2, almost 40 years ago, interest in this compound has flourished in several research areas. In this paper, we present a convenient, high-yielding (99% overall) method for the preparation of milligram to multigram quantities of 2 (as the b...

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Veröffentlicht in:Organic letters 2006-01, Vol.8 (2), p.187-189
1. Verfasser: Boyle, Nicholas A
Format: Artikel
Sprache:eng
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Zusammenfassung:Since the first disclosure of difluoromethylenediphosphonate, 2, almost 40 years ago, interest in this compound has flourished in several research areas. In this paper, we present a convenient, high-yielding (99% overall) method for the preparation of milligram to multigram quantities of 2 (as the bis(tributylammonium salt, 2b) in a solid form that is easy to handle.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0522889