Difluoromethylenediphosphonate: A Convenient, Scalable, and High-Yielding Synthesis
Since the first disclosure of difluoromethylenediphosphonate, 2, almost 40 years ago, interest in this compound has flourished in several research areas. In this paper, we present a convenient, high-yielding (99% overall) method for the preparation of milligram to multigram quantities of 2 (as the b...
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Veröffentlicht in: | Organic letters 2006-01, Vol.8 (2), p.187-189 |
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Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Since the first disclosure of difluoromethylenediphosphonate, 2, almost 40 years ago, interest in this compound has flourished in several research areas. In this paper, we present a convenient, high-yielding (99% overall) method for the preparation of milligram to multigram quantities of 2 (as the bis(tributylammonium salt, 2b) in a solid form that is easy to handle. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol0522889 |