A Concise Synthesis of Enantioenriched Fluorinated Carbocycles

A Concise Synthesis of Enantioenriched Fluorinated Carbocycles

A “reverse” cycloaddition–fluorination strategy has been validated to access enantioenriched fluorinated compounds featuring up to five stereogenic centers, one of which is fluorinated. This highly convergent process features a mild and high‐yielding fluorination, for which the sense and level of st...

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Veröffentlicht in:Angewandte Chemie International Edition 2007-01, Vol.46 (27), p.5106-5110
Hauptverfasser: Lam, Yu-hong, Bobbio, Carla, Cooper, Ian R., Gouverneur, Véronique
Format: Artikel
Sprache:eng
Schlagworte:
allylic compounds
asymmetric catalysis
Cyclization
Diels-Alder reaction
electrophilic fluorination
Fluorine - chemistry
Molecular Structure
Organic Chemicals - chemical synthesis
Organic Chemicals - chemistry
Oxidation-Reduction
Stereoisomerism
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Zusammenfassung:A “reverse” cycloaddition–fluorination strategy has been validated to access enantioenriched fluorinated compounds featuring up to five stereogenic centers, one of which is fluorinated. This highly convergent process features a mild and high‐yielding fluorination, for which the sense and level of stereocontrol have been probed.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200701365