Rapid thyrotoxicosis in anaplastic thyroid carcinoma

We present the case of a 71-year-old man with anaplastic thyroid cancer. On presentation, his thyroid function was normal, but he subsequently developed sudden, rapid thyrotoxicosis. Thyrotoxicosis in anaplastic thyroid carcinoma is very rare, but in all previously reported cases the patient was thy...

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Veröffentlicht in:	Journal of laryngology and otology 2007-07, Vol.121 (7), p.695-697
Hauptverfasser:	Phillips, J S, Pledger, D R, Hilger, A W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anaplastic Carcinoma Biological and medical sciences Biopsy, Needle Carcinoma - complications Clinical Records Diagnosis, Differential Endocrinopathies Fatal Outcome Humans Male Malignant tumors Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Otorhinolaryngology. Stomatology Thyroid Function Tests Thyroid Neoplasms Thyroid Neoplasms - complications Thyroid. Thyroid axis (diseases) Thyrotoxicosis Thyrotoxicosis - etiology
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Beschreibung
Zusammenfassung:	We present the case of a 71-year-old man with anaplastic thyroid cancer. On presentation, his thyroid function was normal, but he subsequently developed sudden, rapid thyrotoxicosis. Thyrotoxicosis in anaplastic thyroid carcinoma is very rare, but in all previously reported cases the patient was thyrotoxic at presentation. Our case is unusual as our patient presented euthyroid, and thyrotoxicosis developed subsequently. We challenge current ideas regarding the biochemical pathophysiology of rapid thyrotoxicosis in anaplastic thyroid carcinoma and provide an alternative explanation.
ISSN:	0022-2151 1748-5460
DOI:	10.1017/S0022215106005330