Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in Men

Association of Lipopolysaccharide-Binding Protein and Coronary Artery Disease in Men Philipp M. Lepper, Christian Schumann, Kathy Triantafilou, F. Maximilian Rasche, Tibor Schuster, Hedwig Frank, E. Marion Schneider, Martha Triantafilou, Maximilian von Eynatten Lipopolysaccharide-binding protein (LBP) is the first protein to encounter lipopolysaccharide and to deliver it to toll-like receptors; therefore, its presence might be a reliable biomarker indicating activation of innate immunity. We tested the hypothesis that LBP might be used as a biomarker for coronary artery disease (CAxD). In 247 men undergoing elective coronary angiography, serum LBP concentration was significantly increased in 172 patients with confirmed CAD compared with 75 individuals without coronary atherosclerosis. In adjusted multivariable logistic regression analyses, LBP was a significant and independent predictor of prevalent CAD. Lipopolysaccharide-binding protein might serve as a novel marker for CAD in men.