DICHLOROACETATE TREATMENT FOR SEVERE REFRACTORY METABOLIC ACIDOSIS DURING NEONATAL SEPSIS

We describe a preterm neonate with documented group B Streptococcus sepsis and associated metabolic acidosis whose lactic acidemia was refractory to conventional sodium bicarbonate therapy but responded well to dichloroacetate treatment.

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Bibliographische Detailangaben
Veröffentlicht in:	The Pediatric infectious disease journal 2001-02, Vol.20 (2), p.218-219
Hauptverfasser:	Arnon, Shmuel, Litmanovits, Ita, Regev, Rivka, Elpeleg, Orly, Dolfin, Tzipora
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis, Lactic - drug therapy Acidosis, Lactic - etiology Biological and medical sciences Dichloroacetic Acid - therapeutic use General and cellular metabolism. Vitamins Humans Infant, Newborn Medical sciences Pharmacology. Drug treatments Sepsis - complications Sodium Bicarbonate - therapeutic use Streptococcal Infections - complications
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Beschreibung
Zusammenfassung:	We describe a preterm neonate with documented group B Streptococcus sepsis and associated metabolic acidosis whose lactic acidemia was refractory to conventional sodium bicarbonate therapy but responded well to dichloroacetate treatment.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/00006454-200102000-00021