DOK4/IRS‐5 expression is altered in clear cell renal cell carcinoma

The insulin‐receptor substrate family plays important roles in cellular growth, signaling, and survival. We have previously shown the dysregulation of the IGF‐axis in clear cell renal cell carcinoma. In this manuscript, we examine the expression of the insulin receptor substrate family in clear cell RCC, and demonstrate that the expression of 2 members of this family are significantly altered in tumors. The most striking finding is that expression of the new IRS family member IRS‐5 is significantly upregulated in 90% of examined clear cell RCCs. Studies on this gene has shown that it is regulated through chromatin remodeling in kidney cells. © 2007 Wiley‐Liss, Inc.