Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine

8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D 4-receptor ligand was synthesized using oxidative iododestannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-07, Vol.17 (14), p.4066-4069
Hauptverfasser:	Joshua, Alummoottil V., Sharma, Sanjay K., Strelkov, Alicia, Scott, John R., Martin-Iverson, Mathew T., Abrams, Douglas N., Silverstone, Peter H., McEwan, Alexander J.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - metabolism Clozapine Clozapine - analogs & derivatives Clozapine - chemical synthesis Clozapine - metabolism Clozapine - pharmacokinetics Contrast media. Radiopharmaceuticals D 4 receptors Iozapine Medical sciences Mice Pharmacology. Drug treatments Rabbits Receptors, Dopamine D4 - metabolism Schizophrenia Tissue Distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D 4-receptor ligand was synthesized using oxidative iododestannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits. 8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D 4-receptor ligand was synthesized using oxidative iodo-destannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.04.069