Vessel Dilator and Kaliuretic Peptide Inhibit MEK 1/2 Activation in Human Prostate Cancer Cells

Background: Vessel dilator and kaliuretic peptide have anticancer effects in human prostate adenocarcinomas. Materials and Methods: The effect of vessel dilator, kaliuretic peptide and cyclic GMP on MEK 1/2 kinase were examined in human prostate adenocarcinoma cells. Results: Vessel dilator and kali...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Anticancer research 2007-05, Vol.27 (3B), p.1387-1392
Hauptverfasser:	YING SUN, EICHELBAUM, Ehrentraud J, HAI WANG, VESELY, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Antibodies - pharmacology Antineoplastic Agents - pharmacology Atrial Natriuretic Factor - pharmacology Biological and medical sciences Cell Line, Tumor Cyclic GMP - antagonists & inhibitors Cyclic GMP - metabolism Enzyme Activation Humans Male MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 2 - antagonists & inhibitors Medical sciences Nephrology. Urinary tract diseases Peptide Fragments - pharmacology Phosphorylation - drug effects Prostatic Neoplasms - enzymology Protein Precursors - pharmacology Tumors Tumors of the urinary system Urinary tract. Prostate gland
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background: Vessel dilator and kaliuretic peptide have anticancer effects in human prostate adenocarcinomas. Materials and Methods: The effect of vessel dilator, kaliuretic peptide and cyclic GMP on MEK 1/2 kinase were examined in human prostate adenocarcinoma cells. Results: Vessel dilator and kaliuretic peptide decreased the activation of MEK 1/2 over a concentration range of 0.01 Î¼M to 10 Î¼M. Vessel dilator and kaliuretic peptide (each 10 Î¼M) inhibited the phosphorylation of MEK 1/2 kinase by 98% (p
ISSN:	0250-7005 1791-7530