Cyathusals A, B, and C, Antioxidants from the Fermented Mushroom Cyathus stercoreus

Three new polyketide-type antioxidative compounds, cyathusals A (1), B (2), and C (3), and the known pulvinatal (4) were obtained from the fermented mushroom Cyathus stercoreus. The structures of the compounds were characterized on the basis of NMR and mass spectroscopic data. Cyathusals A, B, and C...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2007-06, Vol.70 (6), p.1043-1045
Hauptverfasser:	Kang, Hahk-Soo, Jun, Eun-Mi, Park, Soon-Hye, Heo, Soo-Jin, Lee, Tae-Soo, Yoo, Ick-Dong, Kim, Jong-Pyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry antioxidant activity antioxidants Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Basidiomycota Biological and medical sciences Biotechnology Biphenyl Compounds chemical structure Cyathus stercoreus cyathusal Fermentation Free Radical Scavengers - chemistry Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Fundamental and applied biological sciences. Psychology Heterocyclic Compounds, 3-Ring - chemistry Heterocyclic Compounds, 3-Ring - isolation & purification Heterocyclic Compounds, 3-Ring - pharmacology Korea medicinal properties Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology mushrooms Nuclear Magnetic Resonance, Biomolecular Picrates - pharmacology polyketides pulvinatal spectral analysis
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Zusammenfassung:	Three new polyketide-type antioxidative compounds, cyathusals A (1), B (2), and C (3), and the known pulvinatal (4) were obtained from the fermented mushroom Cyathus stercoreus. The structures of the compounds were characterized on the basis of NMR and mass spectroscopic data. Cyathusals A, B, and C and pulvinatal showed free radical scavenging activities on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with EC50 values of 41.6, 46.0, 26.6, and 28.6 μM, respectively, and on the 2,2‘-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) cation radical with EC50 values of 7.9, 11.1, 9.1, and 8.4 μM, respectively.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np060637h