Novel Polymer-Supported Chiral Catalysts for the Asymmetric Addition of Diethylzinc to Aldehydes

Novel Polymer-Supported Chiral Catalysts for the Asymmetric Addition of Diethylzinc to Aldehydes

Newly synthesized polymer-supported chiral amino alcohol catalysts 5a and 5b have been proved to be effective for the enantioselective addition of diethylzinc to aldehydes, affording the corresponding sec-alcohols in moderate enantiomeric excesses with good to excellent yields. The recycled catalyst...

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Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2007, Vol.55(7), pp.1011-1013
Hauptverfasser: Wang, Su-Xi, Chen, Fen-Er
Format: Artikel
Sprache:eng
Schlagworte:
aldehyde
Aldehydes - chemistry
amino alcohol
Catalysis
diethylzinc
enantioseletivity
Molecular Structure
Organometallic Compounds - chemistry
polymer-supported
Polymers - chemistry
Stereoisomerism
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Zusammenfassung:Newly synthesized polymer-supported chiral amino alcohol catalysts 5a and 5b have been proved to be effective for the enantioselective addition of diethylzinc to aldehydes, affording the corresponding sec-alcohols in moderate enantiomeric excesses with good to excellent yields. The recycled catalyst could be reused in the same reaction without significant deterioration in performance.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.55.1011