Simultaneous assay of metformin and glibenclamide in human plasma based on extraction-less sample preparation procedure and LC/(APCI)MS

Separation of metformin and glibenclamide was achieved within a single chromatographic run on a Zorbax CN column, under isocratic conditions, using acetonitrile and aqueous component (0.01 moles/L ammonium acetate adjusted at pH 3.5 with acetic acid) in volumetric ratio 1/1. Plasma sample preparatio...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2007-07, Vol.854 (1), p.211-218
Hauptverfasser:	Georgita, Cristina, Albu, Florin, David, Victor, Medvedovici, Andrei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Analytical, structural and metabolic biochemistry Anti-diabetic combination APCI Bioequivalence Biological and medical sciences Chromatography, Liquid - methods Extraction-less sample preparation Female Fundamental and applied biological sciences. Psychology General pharmacology Glibenclamide Glyburide - blood Glyburide - pharmacokinetics Human plasma Humans Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacokinetics Male Mass Spectrometry - methods Medical sciences Metformin Metformin - blood Metformin - pharmacokinetics Method validation MS detection Pharmacokinetic parameters Pharmacology. Drug treatments Sensitivity and Specificity Simultaneous assay Therapeutic Equivalency
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