Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates
The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2001-02, Vol.19 (15), p.1906-1910 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1910 |
|---|---|
| container_issue | 15 |
| container_start_page | 1906 |
| container_title | Vaccine |
| container_volume | 19 |
| creator | Ohara, Naoya Matsuoka, Masanori Nomaguchi, Hiroko Naito, Mariko Yamada, Takeshi |
| description | The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant
Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of
Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG. |
| doi_str_mv | 10.1016/S0264-410X(00)00439-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70652954</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X00004394</els_id><sourcerecordid>17841086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c486t-d8e97fcaecc6d719ba67fe3ca9bbb68a32e15b6d0d6a705865b5ed47aa4169033</originalsourceid><addsrcrecordid>eNqFkc2KFDEQx4Mo7rj6CEpAED20Jv2R7j6JDroKKwoqeAuVpHqMdCe9SXpwHsmH8OSLmflg97inhOJXVX_qR8hjzl5yxsWrr6wUdVFz9uM5Yy8Yq6u-qO-QFe_aqigb3t0lq2vkjDyI8RdjrKl4f5-ccV6WXSXYivz9EnxCnewWacA4excxUtiAdTFR_D1jsBO6BCP9tNNegU65skx0xDkAUuuGfbd3-Ucnq_cVs2g0VO3yQO0nZR24RN-CtuO4RLqGccKUsLhY_v0JuctvMRRz8LnNug1NPwMinZcEh1DzTb48xm7QUQ3OWAMJ40Nyb4Ax4qPTe06-v3_3bf2huPx88XH95rLQdSdSYTrs20EDai1My3sFoh2w0tArpUQHVYm8UcIwI6BlTSca1aCpW4Cai55V1Tl5dpyb01wtGJOcbNQ4juDQL1G2TDRl39S3grztso9OZLA5gjr4GAMOcs6HhrCTnMm9YHkQLPf2JGPyIFjuFzw5LVjUhOam62Q0A09PAEQN4xDAaRuvuV60Zd9n6vWRwny1rcUgo7bosjebpSVpvL0lyH__B8ne</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17841086</pqid></control><display><type>article</type><title>Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ohara, Naoya ; Matsuoka, Masanori ; Nomaguchi, Hiroko ; Naito, Mariko ; Yamada, Takeshi</creator><creatorcontrib>Ohara, Naoya ; Matsuoka, Masanori ; Nomaguchi, Hiroko ; Naito, Mariko ; Yamada, Takeshi</creatorcontrib><description>The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant
Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of
Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(00)00439-4</identifier><identifier>PMID: 11228360</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Ag85 ; Ag85 protein ; Animals ; Antigens, Bacterial - genetics ; Bacteriology ; Base Sequence ; BCG ; BCG Vaccine - genetics ; BCG Vaccine - immunology ; BCG Vaccine - pharmacology ; Biological and medical sciences ; DNA Primers - genetics ; Fundamental and applied biological sciences. Psychology ; Leprosy ; Leprosy - immunology ; Leprosy - prevention & control ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Microbiology ; Mycobacterium bovis - genetics ; Mycobacterium bovis - immunology ; Mycobacterium leprae ; Mycobacterium leprae - genetics ; Mycobacterium leprae - growth & development ; Mycobacterium leprae - immunology ; Plasmids - genetics ; Recombinant ; Spleen - immunology ; Vaccine ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Synthetic - genetics ; Vaccines, Synthetic - immunology ; Vaccines, Synthetic - pharmacology</subject><ispartof>Vaccine, 2001-02, Vol.19 (15), p.1906-1910</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-d8e97fcaecc6d719ba67fe3ca9bbb68a32e15b6d0d6a705865b5ed47aa4169033</citedby><cites>FETCH-LOGICAL-c486t-d8e97fcaecc6d719ba67fe3ca9bbb68a32e15b6d0d6a705865b5ed47aa4169033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(00)00439-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=967299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11228360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohara, Naoya</creatorcontrib><creatorcontrib>Matsuoka, Masanori</creatorcontrib><creatorcontrib>Nomaguchi, Hiroko</creatorcontrib><creatorcontrib>Naito, Mariko</creatorcontrib><creatorcontrib>Yamada, Takeshi</creatorcontrib><title>Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant
Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of
Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG.</description><subject>Ag85</subject><subject>Ag85 protein</subject><subject>Animals</subject><subject>Antigens, Bacterial - genetics</subject><subject>Bacteriology</subject><subject>Base Sequence</subject><subject>BCG</subject><subject>BCG Vaccine - genetics</subject><subject>BCG Vaccine - immunology</subject><subject>BCG Vaccine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>DNA Primers - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Leprosy</subject><subject>Leprosy - immunology</subject><subject>Leprosy - prevention & control</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>Mycobacterium bovis - genetics</subject><subject>Mycobacterium bovis - immunology</subject><subject>Mycobacterium leprae</subject><subject>Mycobacterium leprae - genetics</subject><subject>Mycobacterium leprae - growth & development</subject><subject>Mycobacterium leprae - immunology</subject><subject>Plasmids - genetics</subject><subject>Recombinant</subject><subject>Spleen - immunology</subject><subject>Vaccine</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, Synthetic - genetics</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Vaccines, Synthetic - pharmacology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEQx4Mo7rj6CEpAED20Jv2R7j6JDroKKwoqeAuVpHqMdCe9SXpwHsmH8OSLmflg97inhOJXVX_qR8hjzl5yxsWrr6wUdVFz9uM5Yy8Yq6u-qO-QFe_aqigb3t0lq2vkjDyI8RdjrKl4f5-ccV6WXSXYivz9EnxCnewWacA4excxUtiAdTFR_D1jsBO6BCP9tNNegU65skx0xDkAUuuGfbd3-Ucnq_cVs2g0VO3yQO0nZR24RN-CtuO4RLqGccKUsLhY_v0JuctvMRRz8LnNug1NPwMinZcEh1DzTb48xm7QUQ3OWAMJ40Nyb4Ax4qPTe06-v3_3bf2huPx88XH95rLQdSdSYTrs20EDai1My3sFoh2w0tArpUQHVYm8UcIwI6BlTSca1aCpW4Cai55V1Tl5dpyb01wtGJOcbNQ4juDQL1G2TDRl39S3grztso9OZLA5gjr4GAMOcs6HhrCTnMm9YHkQLPf2JGPyIFjuFzw5LVjUhOam62Q0A09PAEQN4xDAaRuvuV60Zd9n6vWRwny1rcUgo7bosjebpSVpvL0lyH__B8ne</recordid><startdate>20010228</startdate><enddate>20010228</enddate><creator>Ohara, Naoya</creator><creator>Matsuoka, Masanori</creator><creator>Nomaguchi, Hiroko</creator><creator>Naito, Mariko</creator><creator>Yamada, Takeshi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010228</creationdate><title>Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates</title><author>Ohara, Naoya ; Matsuoka, Masanori ; Nomaguchi, Hiroko ; Naito, Mariko ; Yamada, Takeshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-d8e97fcaecc6d719ba67fe3ca9bbb68a32e15b6d0d6a705865b5ed47aa4169033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Ag85</topic><topic>Ag85 protein</topic><topic>Animals</topic><topic>Antigens, Bacterial - genetics</topic><topic>Bacteriology</topic><topic>Base Sequence</topic><topic>BCG</topic><topic>BCG Vaccine - genetics</topic><topic>BCG Vaccine - immunology</topic><topic>BCG Vaccine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>DNA Primers - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Leprosy</topic><topic>Leprosy - immunology</topic><topic>Leprosy - prevention & control</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Mycobacterium bovis - genetics</topic><topic>Mycobacterium bovis - immunology</topic><topic>Mycobacterium leprae</topic><topic>Mycobacterium leprae - genetics</topic><topic>Mycobacterium leprae - growth & development</topic><topic>Mycobacterium leprae - immunology</topic><topic>Plasmids - genetics</topic><topic>Recombinant</topic><topic>Spleen - immunology</topic><topic>Vaccine</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, Synthetic - genetics</topic><topic>Vaccines, Synthetic - immunology</topic><topic>Vaccines, Synthetic - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohara, Naoya</creatorcontrib><creatorcontrib>Matsuoka, Masanori</creatorcontrib><creatorcontrib>Nomaguchi, Hiroko</creatorcontrib><creatorcontrib>Naito, Mariko</creatorcontrib><creatorcontrib>Yamada, Takeshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohara, Naoya</au><au>Matsuoka, Masanori</au><au>Nomaguchi, Hiroko</au><au>Naito, Mariko</au><au>Yamada, Takeshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2001-02-28</date><risdate>2001</risdate><volume>19</volume><issue>15</issue><spage>1906</spage><epage>1910</epage><pages>1906-1910</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The components of Ag85 (Ag85A, Ag85B, and Ag85C) are putative protective antigen candidates against mycobacterial infection. A recombinant
Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) over-producing Ag85A, Ag85B, and MPB51 (rBCG/BA51) was constructed. rBCG/BA51 could secrete these antigens at levels more than five times higher than parental BCG. Immunization of C57BL/6 and BALB/c mice with this rBCG reduced the multiplication of
Mycobacterium leprae in the foot pads of both strains of mice. The inhibition by rBCG/BA51 was more evident than that by parental BCG.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11228360</pmid><doi>10.1016/S0264-410X(00)00439-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2001-02, Vol.19 (15), p.1906-1910 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70652954 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Ag85 Ag85 protein Animals Antigens, Bacterial - genetics Bacteriology Base Sequence BCG BCG Vaccine - genetics BCG Vaccine - immunology BCG Vaccine - pharmacology Biological and medical sciences DNA Primers - genetics Fundamental and applied biological sciences. Psychology Leprosy Leprosy - immunology Leprosy - prevention & control Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbiology Mycobacterium bovis - genetics Mycobacterium bovis - immunology Mycobacterium leprae Mycobacterium leprae - genetics Mycobacterium leprae - growth & development Mycobacterium leprae - immunology Plasmids - genetics Recombinant Spleen - immunology Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - pharmacology |
| title | Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T22%3A11%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20responses%20against%20experimental%20Mycobacterium%20leprae%20infection%20in%20mice%20induced%20by%20recombinant%20Bacillus%20Calmette-Gu%C3%A9rin%20over-producing%20three%20putative%20protective%20antigen%20candidates&rft.jtitle=Vaccine&rft.au=Ohara,%20Naoya&rft.date=2001-02-28&rft.volume=19&rft.issue=15&rft.spage=1906&rft.epage=1910&rft.pages=1906-1910&rft.issn=0264-410X&rft.eissn=1873-2518&rft.coden=VACCDE&rft_id=info:doi/10.1016/S0264-410X(00)00439-4&rft_dat=%3Cproquest_cross%3E17841086%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17841086&rft_id=info:pmid/11228360&rft_els_id=S0264410X00004394&rfr_iscdi=true |