Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?

Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restore...

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Veröffentlicht in:	Brain research 2001-03, Vol.893 (1), p.268-272
Hauptverfasser:	Rao, A.Muralikrishna, Hatcher, J.F., Dempsey, R.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis, Cardiolipin Arachidonic acid Arachidonic Acid - metabolism Biological and medical sciences cardiolipin Cardiolipins - chemistry Cardiolipins - metabolism Citicoline Cytidine Diphosphate Choline - administration & dosage Disease Models, Animal Enzyme Activation - drug effects Fatty Acids - analysis Fatty Acids - metabolism Gerbillinae Hippocampus - drug effects Hippocampus - metabolism Injections, Intraperitoneal Ischemic Attack, Transient - metabolism Isoenzymes - metabolism Lysophospholipids, Mitochondria Male Medical sciences Meriones unguiculatus Neurology Neuronal death Nootropic Agents - administration & dosage Phosphatidylcholine Phosphatidylcholines - chemistry Phosphatidylcholines - metabolism Phosphatidylinositol Phosphatidylinositols - chemistry Phosphatidylinositols - metabolism phosphatidylinotisol Phospholipase A 2 Phospholipase D - metabolism Phospholipases - metabolism Phospholipases A - metabolism Prosencephalon - blood supply Prosencephalon - metabolism Type C Phospholipases - metabolism Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. These data suggest that CDP-choline prevented the activation of phospholipase A 2 (rather than inhibiting phospholipase A 2 activity) but did not affect activities of PtdCho-phospholipases C and/or D, or phosphoinositide-phospholipase C. CDP-choline also provided significant protection for hippocampal CA 1 neurons.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(00)03280-7