Increased L-arginine uptake and inducible nitric oxide synthase activity in aortas of rats with heart failure

Cardiology Research Laboratory, Departments of Medicine, Pharmacology, and Toxicology, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada N6A 4G5 L -Arginine crosses the cell membrane primarily through the system y + transporter. The aim of this study was to invest...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2001-02, Vol.280 (2), p.H859-H867
Hauptverfasser:	Stathopulos, Peter B, Lu, Xiangru, Shen, Ji, Scott, Jeremy A, Hammond, James R, McCormack, David G, Arnold, J. Malcolm O, Feng, Qingping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - enzymology Arginine - pharmacokinetics Blood Pressure - physiology Disease Models, Animal DNA Primers Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology Gene Expression Regulation, Enzymologic Heart Failure - metabolism Heart Rate - physiology Male NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Rats Rats, Sprague-Dawley Tritium Tumor Necrosis Factor-alpha - genetics Ventricular Pressure - physiology
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Beschreibung
Zusammenfassung:	Cardiology Research Laboratory, Departments of Medicine, Pharmacology, and Toxicology, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada N6A 4G5 L -Arginine crosses the cell membrane primarily through the system y + transporter. The aim of this study was to investigate the role of L -arginine transport in nitric oxide (NO) production in aortas of rats with heart failure induced by myocardial infarction. Tumor necrosis factor- levels in aortas of rats with heart failure were six times higher than in sham rats ( P
ISSN:	0363-6135 1522-1539
DOI:	10.1152/ajpheart.2001.280.2.h859