Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice
The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT(1A) agonis...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2001-04, Vol.24 (4), p.391-398 |
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| creator | O'Neill, M F Conway, M W |
| description | The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT(1A) agonist 8-OH-DPAT decreased immobility in the forced swim test in mice as previously described. Both the selective 5-HT(1B) agonist anpirtoline (1.25-5 mg/kg) and mixed 5-HT(1A/B) agonist RU24969 (0.6-2.5 mg/kg) significantly increased time spent swimming in the FST. |
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The 5-HT(1A) agonist 8-OH-DPAT decreased immobility in the forced swim test in mice as previously described. 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| identifier | ISSN: 0893-133X |
| ispartof | Neuropsychopharmacology (New York, N.Y.), 2001-04, Vol.24 (4), p.391-398 |
| issn | 0893-133X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70640998 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Antidepressive Agents, Tricyclic - pharmacology Behavior, Animal - drug effects Behavior, Animal - physiology Dose-Response Relationship, Drug Female Imipramine - pharmacology Indoles - pharmacology Mice Mice, Inbred Strains Motor Activity - drug effects Motor Activity - physiology Oxadiazoles - pharmacology Piperazines - pharmacology Piperidines - pharmacology Pyridines - pharmacology Reaction Time - drug effects Receptor, Serotonin, 5-HT1B Receptors, Serotonin - physiology Receptors, Serotonin, 5-HT1 Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Swimming - physiology |
| title | Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice |
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