Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice

The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT(1A) agonis...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2001-04, Vol.24 (4), p.391-398
Hauptverfasser:	O'Neill, M F, Conway, M W
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Antidepressive Agents, Tricyclic - pharmacology Behavior, Animal - drug effects Behavior, Animal - physiology Dose-Response Relationship, Drug Female Imipramine - pharmacology Indoles - pharmacology Mice Mice, Inbred Strains Motor Activity - drug effects Motor Activity - physiology Oxadiazoles - pharmacology Piperazines - pharmacology Piperidines - pharmacology Pyridines - pharmacology Reaction Time - drug effects Receptor, Serotonin, 5-HT1B Receptors, Serotonin - physiology Receptors, Serotonin, 5-HT1 Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Swimming - physiology
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Zusammenfassung:	The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT(1A) agonist 8-OH-DPAT decreased immobility in the forced swim test in mice as previously described. Both the selective 5-HT(1B) agonist anpirtoline (1.25-5 mg/kg) and mixed 5-HT(1A/B) agonist RU24969 (0.6-2.5 mg/kg) significantly increased time spent swimming in the FST.
ISSN:	0893-133X