Post-hypoxic magnesium decreases nuclear oxidative damage in the fetal guinea pig brain

This study was to determine if administration of MgSO 4 after the hypoxic insult (post-hypoxia) would attenuate neuronal damage in the fetal guinea pig brain. Pregnant guinea pigs (45–60 days gestation) were exposed to hypoxia (7% O 2) for 1 h. Following hypoxia, one group recovered for 24 h with no additional treatment (post-hypoxia) and another group received MgSO 4, 300 mg/kg i.p., followed by 100 mg/kg i.p., each hour for three doses (post-hypoxia+Mg) and allowed to recover for 24 h. Fetal brain magnesium content was decreased ( P