Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin

1 Diabetes Center and Clinical Research Institute of Kyoto National Hospital, Kyoto 612-8555; 2 Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507; and 3 Pharmaceutical Research Division, Takeda Chemical Industries, Osaka, Japan 532-8686 Lept...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2001-02, Vol.280 (2), p.E334-E339
Hauptverfasser:	Matsuoka, Naoki, Ogawa, Yoshihiro, Masuzaki, Hiroaki, Ebihara, Ken, Aizawa-Abe, Megumi, Satoh, Noriko, Ishikawa, Eiichiro, Fujisawa, Yukio, Kosaki, Atsushi, Yamada, Kazunori, Kuzuya, Hideshi, Nakao, Kazuwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dietary Fats - pharmacology Leptin - blood Leptin - genetics Lipase - blood Lipid Metabolism Lipids - blood Lipoproteins - blood Lipoproteins - chemistry Liver - metabolism Male Mice Mice, Transgenic - genetics Thinness - genetics Triglycerides - analysis Triglycerides - pharmacology
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Zusammenfassung:	1 Diabetes Center and Clinical Research Institute of Kyoto National Hospital, Kyoto 612-8555; 2 Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507; and 3 Pharmaceutical Research Division, Takeda Chemical Industries, Osaka, Japan 532-8686 Leptin is an adipocyte-derived circulating satiety factor with a variety of biological effects. Evidence has accumulated suggesting that leptin may modulate glucose and lipid metabolism. In the present study, we examined lipid metabolism in transgenic skinny mice with elevated plasma leptin concentrations. The plasma concentrations of triglycerides and free fatty acids in transgenic skinny mice were 71.5 ( P
ISSN:	0193-1849 1522-1555
DOI:	10.1152/ajpendo.2001.280.2.e334