A DNA vaccine encoding a peptide mimic of Streptococcus pneumoniae serotype 4 capsular polysaccharide induces specific anti-carbohydrate antibodies in Balb/c mice

Streptococcus pneumoniae is a leading cause of morbidity and mortality in both the developing and developed world. The T-independent nature of the current polysaccharide vaccine renders it ineffective in elderly adults and children

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2001-02, Vol.19 (13), p.1717-1726
Hauptverfasser:	Lesinski, Gregory B, Smithson, S.Louise, Srivastava, Neeti, Chen, Dexiang, Widera, Georg, Westerink, M.A.Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Bacterial - immunology Antibodies, Monoclonal - immunology Antibody Affinity Antibody Specificity - immunology Bacteriology Base Sequence Biological and medical sciences carbohydrates Cloning, Molecular DNA vaccines Drug Delivery Systems Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Genetic Vectors - genetics Mice Mice, Inbred BALB C Microbiology Microspheres Molecular Mimicry - genetics Molecular Mimicry - immunology Molecular Sequence Data Peptide Library Peptide mimicry Peptides - chemistry Peptides - genetics Peptides - immunology Pneumococcal Vaccines - genetics Pneumococcal Vaccines - immunology polysaccharides Polysaccharides, Bacterial - chemistry Polysaccharides, Bacterial - immunology Streptococcus pneumoniae Streptococcus pneumoniae - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - genetics Vaccines, DNA - immunology
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Beschreibung
Zusammenfassung:	Streptococcus pneumoniae is a leading cause of morbidity and mortality in both the developing and developed world. The T-independent nature of the current polysaccharide vaccine renders it ineffective in elderly adults and children
ISSN:	0264-410X 1873-2518
DOI:	10.1016/S0264-410X(00)00397-2