Circulating Leptin Levels and Weight Loss in Alzheimer’s Disease Patients

Weight loss is common in Alzheimer’s disease (AD) and is predictive of mortality. Leptin, an adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy expenditure. It acts on the hypothalamus to suppress appetite and increase energy expenditure. We undertook this study...

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Veröffentlicht in:	Dementia and geriatric cognitive disorders 2001-03, Vol.12 (2), p.167-170
Hauptverfasser:	Power, Dermot A., Noel, Jacques, Collins, Ronan, O’Neill, Des
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - blood Biological and medical sciences Body Mass Index Cognition Disorders - diagnosis Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Leptin - blood Male Medical sciences Neurology Neuropsychological Tests Original Research Article Severity of Illness Index Weight Loss
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Zusammenfassung:	Weight loss is common in Alzheimer’s disease (AD) and is predictive of mortality. Leptin, an adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy expenditure. It acts on the hypothalamus to suppress appetite and increase energy expenditure. We undertook this study to determine if inappropriately elevated leptin levels play a role in AD-associated weight loss. Serum leptin levels of 8 patients in each of the following groups were determined: (1) AD, body mass index (BMI) >25; (2) AD, BMI 25, and (4) VaD, BMI
ISSN:	1420-8008 1421-9824
DOI:	10.1159/000051252